Benedict Cumberbatch (Victor Frankenstein), Jonny Lee Miller (The Creature), Ella Smith (Gretel/Clarice), John Killoran (Gustav/Constable), Steven Elliott (Klaus), Karl Johnson (De Lacey), Daniel Millar (Felix de Lacey), Lizzie Winkler (Agatha de Lacey), Andreea Padurariu (The Female Creature), William Nye (William Frankenstein), George Harris (M. Frankenstein), Naomie Harris (Elizabeth Lavenza), John Stahl (Ewan), Mark Armstrong (Rab)