Marissa Jaret Winokur (Tracy Turnblad), Harvey Fierstein (Edna Turnblad), Tara Macri (Amber Von Tussle), Darlene Love (Motormouth Maybelle), Diana DeGarmo (Penny Pingleton), Susan Anton (Velma Von Tussle), Drew Carey (Wilbur Turnblad), Nick Jonas (Link Larkin), Corbin Bleu (Seaweed J. Stubbs), John Stamos (Corny Collins), Chyka Jackson (Little Inez), Mo Gaffney (Prudence (Prudy) Pingleton), Michael McDonald (Mr. Pinky)