Javier Muñoz (alt Alexander Hamilton), Phillipa Soo (Eliza Hamilton), Leslie Odom Jr (Aaron Burr), Renée Elise Goldsberry (Angelica Schuyler), Christopher Jackson (George Washington), Daveed Diggs (Marquis de Lafayette/Thomas Jefferson), Okieriete Onaodowan (Hercules Mulligan/James Madison), Anthony Ramos (John Laurens/Philip Hamilton), Jasmine Cephas Jones (Peggy Schuyler/Maria Reynolds), Jonathan Groff (King George III), Sydney Harcourt (James Reynolds/Philip Schuyler/Doctor), Neil Haskell (u/s Samuel Seabury), Jon Rua (Charles Lee), Ephraim Sykes (George Eacker)