Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Ashley De La Rosa (s/b Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Brendon Stimson (u/s Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Kerry Butler (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Patrick Garr (s/w Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), DeMarius R Copes (Christian Wiggins), Kevin Csolak (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Becca Petersen (s/w Taylor Wedell), Kamille Upshaw (Rachel Hamilton), Zurin Villanueva (Grace Akinola), Gianna Yanelli (Sonja Acquino)