Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Ashley Park (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Iain Young (s/w Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Nikhil Saboo (Marwan Jitla), Jonalyn Saxer (Taylor Wedell), Kamille Upshaw (Rachel Hamilton)