Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Bria Jene Williams (u/s Principal Duvall), Susie Carroll (s/w Lizzie Therman/Caroline Krafft), Aaron Alcaraz (s/w Shane Oman), Brittany Nicholas (s/w Grace Akinola)