Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Devon Hadsell (u/s Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Drew Redington (Mr. Heron), Teddy Toye (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Susie Carroll (s/w Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Darius Barnes (Christian Wiggins), Pascal Pastrana (Shane Oman), Riza Takahashi (Sophie Kawachi), Brittany Nicholas (s/w Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Sasha Hollinger (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Gianna Yanelli (Sonja Acquino)