Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Devon Hadsell (u/s Gretchen Wieners), Jonalyn Saxer (u/s Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Brittany Nicholas (s/w Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), DeMarius R Copes (Christian Wiggins), Kevin Csolak (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Becca Petersen (s/w Taylor Wedell), Kamille Upshaw (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Ixchel Cuellar (s/w Sonja Acquino)