Erika Henningsen (Cady Heron), Becca Petersen (u/s Regina George), Ashley Park (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Ezra Knight (t/r Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), DeMarius R Copes (Christian Wiggins), Kevin Csolak (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Jonalyn Saxer (Taylor Wedell), Kamille Upshaw (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Ixchel Cuellar (s/w Sonja Acquino)