Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Cameron Dallas (t/r Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Catherine Brunell (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Drew Redington (Mr. Heron), Teddy Toye (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Darius Barnes (Christian Wiggins), Pascal Pastrana (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Sasha Hollinger (Rachel Hamilton), Gianna Yanelli (Sonja Acquino)