Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Darius Barnes (u/s Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Catherine Brunell (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Drew Redington (Mr. Heron), Teddy Toye (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Aaron Alcaraz (s/w Christian Wiggins), Pascal Pastrana (Shane Oman), Riza Takahashi (Sophie Kawachi), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Brittany Nicholas (s/w Grace Akinola), Gianna Yanelli (Sonja Acquino)