Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Morgan Cane Harrison (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Chris Medlin (s/w Christian Wiggins), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Maria Briggs (s/w Taylor Wedell), Christine Shepard (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Brittany Nicholas (s/w Sonja Acquino)