Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Iain Young (s/w Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Ixchel Cuellar (s/w Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Daniel Switzer (s/w Christian Wiggins), Kevin Cosculluella (Shane Oman), Devon Hadsell (Caitlyn Caussin), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Brittany Nicholas (s/w Grace Akinola), Gianna Yanelli (Sonja Acquino)