Erika Henningsen (Cady Heron), Reneé Rapp (t/r Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Devon Hadsell (u/s Mrs. Heron/Ms. Norbury/Mrs. George), Iain Young (u/s Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Ixchel Cuellar (s/w Dawn Schweitzer), Maria Briggs (s/w Caitlyn Caussin), Brittany Nicholas (s/w Grace Akinola)