Erika Henningsen (Cady Heron), Reneé Rapp (t/r Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Chris Medlin (s/w Tyler Kimble), DeMarius R Copes (Christian Wiggins), Kevin Cosculluella (Shane Oman), Daryl Tofa (Marwan Jitla)