Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Ixchel Cuellar (s/w Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), DeMarius R Copes (Christian Wiggins), Iain Young (s/w Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Jonalyn Saxer (Taylor Wedell), Kamille Upshaw (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Brittany Nicholas (s/w Sonja Acquino)