Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Danielle Wade (s/b Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Collins Conley (Lizzie Therman/Caroline Krafft), Ben Cook (Tyler Kimble), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Jonalyn Saxer (Taylor Wedell), Gianna Yanelli (Sonja Acquino)