Erika Henningsen (Cady Heron), Ashley De La Rosa (s/b Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Ixchel Cuellar (s/w Dawn Schweitzer), Maria Briggs (s/w Caitlyn Caussin), Chris Medlin (s/w Jason Weems), Brittany Nicholas (s/w Grace Akinola)