Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Barrett Wilbert Weed (Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Drew Redington (Mr. Heron), Teddy Toye (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Darius Barnes (Christian Wiggins), Aaron Alcaraz (s/w Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Sasha Hollinger (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Gianna Yanelli (Sonja Acquino)