Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Olivia Kaufmann (s/b Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Daryl Tofa (u/s Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Aaron Alcaraz (s/w Mr. Heron), Tovi Wayne (s/w Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Darius Barnes (Christian Wiggins), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Iain Young (s/w Marwan Jitla), Becca Petersen (Taylor Wedell), Brittany Nicholas (s/w Rachel Hamilton), Bria Jene Williams (Grace Akinola), Gianna Yanelli (Sonja Acquino)