Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), Grey Henson (Damian Hubbard), Jake Swain (u/s Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Aaron Alcaraz (u/s Mr. Heron), Maria Briggs (u/s Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Tovi Wayne (u/s Tyler Kimble), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Brittany Nicholas (s/w Rachel Hamilton), Bria Jene Williams (Grace Akinola), Susie Carroll (s/w Sonja Acquino)