Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Olivia Kaufmann (s/b Janis Sarkisian), Grey Henson (Damian Hubbard), Jake Swain (u/s Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Iain Young (s/w Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Aaron Alcaraz (s/w Tyler Kimble), Darius Barnes (Christian Wiggins), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Brittany Nicholas (s/w Rachel Hamilton), Bria Jene Williams (Grace Akinola), Maria Briggs (s/w Sonja Acquino)