Erika Henningsen (Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Olivia Kaufmann (s/b Janis Sarkisian), Grey Henson (Damian Hubbard), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Iain Young (u/s Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Morgan Cane Harrison (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Daniel Switzer (s/w Tyler Kimble), Darius Barnes (Christian Wiggins), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Brittany Nicholas (Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Becca Petersen (Taylor Wedell), Christine Shepard (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Gianna Yanelli (Sonja Acquino)