Becca Petersen (u/s Cady Heron), Reneé Rapp (Regina George), Krystina Alabado (Gretchen Wieners), Kate Rockwell (Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), Grey Henson (Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Morgan Cane Harrison (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Darius Barnes (Christian Wiggins), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Brittany Nicholas (s/w Taylor Wedell), Christine Shepard (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Susie Carroll (s/w Sonja Acquino)