Erika Henningsen (Cady Heron), Cailen Fu (s/b Regina George), Krystina Alabado (Gretchen Wieners), Devon Hadsell (u/s Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), Brendon Stimson (u/s Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Jennifer Simard (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Aaron Alcaraz (s/w Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Morgan Cane Harrison (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Jake Swain (Tyler Kimble), Kevin Cosculluella (Shane Oman), Riza Takahashi (Sophie Kawachi), Susie Carroll (s/w Caitlyn Caussin), Curtis Holland (Jason Weems), Daryl Tofa (Marwan Jitla), Maria Briggs (s/w Taylor Wedell), Christine Shepard (Rachel Hamilton), Bria Jene Williams (Grace Akinola), Brittany Nicholas (s/w Sonja Acquino)