Erika Henningsen (Cady Heron), Taylor Louderman (Regina George), Ashley Park (Gretchen Wieners), Kate Rockwell (Karen Smith), Gianna Yanelli (u/s Janis Sarkisian), DeMarius R Copes (u/s Damian Hubbard), Kyle Selig (Aaron Samuels), Cheech Manohar (Kevin Gnapoor), Kerry Butler (Mrs. Heron/Ms. Norbury/Mrs. George), Rick Younger (Principal Duvall), Brendon Stimson (Mr. Heron), Myles McHale (Coach Carr/Glen Coco/Math Moderator), Stephanie Lynn Bissonnette (Dawn Schweitzer), Collins Conley (Lizzie Therman/Caroline Krafft), Patrick Garr (s/w Tyler Kimble), Chris Medlin (s/w Christian Wiggins), Kevin Csolak (Shane Oman), Becca Petersen (s/w Sophie Kawachi), Devon Hadsell (Caitlyn Caussin), Curtis Holland (Jason Weems), Nikhil Saboo (Marwan Jitla), Jonalyn Saxer (Taylor Wedell), Kamille Upshaw (Rachel Hamilton), Zurin Villanueva (Grace Akinola), Brittany Nicholas (s/w Sonja Acquino)