Danielle Wade (Cady Heron), Mariah Rose Faith (Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Sarah Crane (u/s Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), Kabir Bery (Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Will Branner (Mr. Heron), Marcus Shane (s/w Coach Carr/Glen Coco/Math Moderator), Sydney Mei Ruf-Wong (Lizzie Therman/Caroline Krafft), Samuel Gerber (s/w Tyler Kimble), DeShawn Bowens (Christian Wiggins), Blake Zelesnikar (Shane Oman), Asia Kreitz (Sophie Kawachi), Mary Beth Donahoe (Caitlyn Caussin), David Wright Jr (Jason Weems), Fernell Hogan (Marwan Jitla), Olivia Renteria (Taylor Wedell), Morgan Ashley Bryant (Rachel Hamilton), Niani Feelings (Grace Akinola), Kaitlyn Louise Smith (Sonja Acquino)