Danielle Wade (Cady Heron), Olivia Renteria (u/s Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Mary Kate Morrissey (Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), David Wright Jr (u/s Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Will Branner (Mr. Heron), Will Branner (Coach Carr/Glen Coco/Math Moderator), Sarah Crane (Dawn Schweitzer), Sydney Mei Ruf-Wong (Lizzie Therman/Caroline Krafft), Sky Flaherty (Tyler Kimble), DeShawn Bowens (Christian Wiggins), Blake Zelesnikar (Shane Oman), Asia Kreitz (Sophie Kawachi), Mary Beth Donahoe (Caitlyn Caussin), Samuel Gerber (s/w Jason Weems), Fernell Hogan (Marwan Jitla), Grace Romanello (s/w Taylor Wedell), Morgan Ashley Bryant (Rachel Hamilton), Niani Feelings (Grace Akinola), Kaitlyn Louise Smith (Sonja Acquino)