Danielle Wade (Cady Heron), English Bernhardt (s/b Regina George), Megan Masako Haley (Gretchen Wieners), Olivia Renteria (u/s Karen Smith), Mary Kate Morrissey (Janis Sarkisian), Eric Huffman (Damian Hubbard), Will Branner (u/s Aaron Samuels), Kabir Bery (Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Samuel Gerber (u/s Mr. Heron), Samuel Gerber (u/s Coach Carr/Glen Coco/Math Moderator), Sarah Crane (Dawn Schweitzer), Sydney Mei Ruf-Wong (Lizzie Therman/Caroline Krafft), DeShawn Bowens (Christian Wiggins), Blake Zelesnikar (Shane Oman), Asia Kreitz (Sophie Kawachi), Mary Beth Donahoe (Caitlyn Caussin), David Wright Jr (Jason Weems), Fernell Hogan (Marwan Jitla), Morgan Ashley Bryant (Rachel Hamilton), Niani Feelings (Grace Akinola), Kaitlyn Louise Smith (Sonja Acquino)