English Bernhardt (s/b Cady Heron), Mariah Rose Faith (Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Sarah Crane (u/s Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), Marcus Shane (u/s Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Samuel Gerber (s/w Mr. Heron), Samuel Gerber (s/w Coach Carr/Glen Coco/Math Moderator), Grace Romanello (s/w Dawn Schweitzer), Ixchel Cuellar (s/w Lizzie Therman/Caroline Krafft), Sky Flaherty (Tyler Kimble), DeShawn Bowens (Christian Wiggins), Blake Zelesnikar (Shane Oman), Asia Kreitz (Sophie Kawachi), Mary Beth Donahoe (Caitlyn Caussin), David Wright Jr (Jason Weems), Fernell Hogan (Marwan Jitla), Olivia Renteria (Taylor Wedell), Morgan Ashley Bryant (Rachel Hamilton), Niani Feelings (Grace Akinola), Kaitlyn Louise Smith (Sonja Acquino)