Danielle Wade (Cady Heron), Mariah Rose Faith (Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Sarah Crane (u/s Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), Kabir Bery (Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Will Branner (Mr. Heron), Will Branner (Coach Carr/Glen Coco/Math Moderator), Ixchel Cuellar (s/w Dawn Schweitzer), Grace Romanello (s/w Caitlyn Caussin)