Danielle Wade (Cady Heron), Mariah Rose Faith (Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Mary Kate Morrissey (Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), Kabir Bery (Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Will Branner (Mr. Heron), Will Branner (Coach Carr/Glen Coco/Math Moderator), Sarah Crane (Dawn Schweitzer), Sydney Mei Ruf-Wong (Lizzie Therman/Caroline Krafft), Sky Flaherty (Tyler Kimble), DeShawn Bowens (Christian Wiggins), Blake Zelesnikar (Shane Oman), Asia Kreitz (Sophie Kawachi), Mary Beth Donahoe (Caitlyn Caussin), David Wright Jr (Jason Weems), Fernell Hogan (Marwan Jitla), Olivia Renteria (Taylor Wedell), Morgan Ashley Bryant (Rachel Hamilton), Niani Feelings (Grace Akinola), Kaitlyn Louise Smith (Sonja Acquino)