Danielle Wade (Cady Heron), Mariah Rose Faith (Regina George), Megan Masako Haley (Gretchen Wieners), Jonalyn Saxer (Karen Smith), Mary Kate Morrissey (Janis Sarkisian), Eric Huffman (Damian Hubbard), Adante Carter (Aaron Samuels), Kabir Bery (Kevin Gnapoor), Gaelen Gilliland (Mrs. Heron/Ms. Norbury/Mrs. George), Lawrence Street (Principal Duvall), Will Branner (Mr. Heron), Will Branner (Coach Carr/Glen Coco/Math Moderator)