Jake Gyllenhaal (Georges Seurat / George), Annaleigh Ashford (Dot / Marie), Phylicia Rashad (Old Lady), Lisa Howard (Nurse), Zachary Levi (Jules), Carmen Cusack (Yvonne), Claybourne Elder (Soldier), Solea Pfeiffer (Celeste #1), Lauren Worsham (Celeste #2), Gabriel Ebert (Franz), Brooks Ashmanskas (Mr.), Liz McCartney (Mrs.), Ruthie Ann Miles (Frieda), Phillip Boykin (Boatman), Jordan Gelber (Louis), Gabriella Pizzolo (Louise), Zachary Levi (Bob Greenberg), Gabriel Ebert (Dennis), Carmen Cusack (Naomi Eisen), Lauren Worsham (Elaine), Lisa Howard (Harriet Pawling), Jordan Gelber (Billy Webster), Brooks Ashmanskas (Charles Redmond), Claybourne Elder (Alex), Ruthie Ann Miles (Betty), Phillip Boykin (Lee Randolph), Phylicia Rashad (Blair Daniels), Lisa Howard (Samantha), Solea Pfeiffer (Theresa), Jaime Rosenstein, Max Chernin, Michael McElroy, Stephanie Jae Park